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This is a two-parameter system of Bloom-Richardson nuclear grade and necrosis:
| non-high nuclear grade (NHNG) | high nuclear grade (HNG) with or without necrosis group 3 |
| NHNG without (absent to slight) necrosis group 1 | NHNG with (affecting 30% or more) necrosis group 2 |
Reference: Fisher, et. al., Cancer, 86 (3):429-438. 1 August 1999.
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